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渡辺 智; 橋本 和幸; 石岡 典子
JAEA-Review 2014-050, JAEA Takasaki Annual Report 2013, P. 102, 2015/03
As part of basic studies for the production of 
Lu capable of labeling of Lu-1,4,7,10-tetraazacyclododecan-N,N',N'',N'''-tetraacetic acid (DOTA)-antibody, Lu complexation of DOTA and diethylenetriamine-N,N,N',N'',N''-pentaacetic acid (DTPA) was investigated in the presence of competing metals: Mg, Cu, and Yb in addition to Ca, Fe, and Zn. The inhibition of Lu complexation by the competing metals was in the order of Mg, Ca 
Fe Yb Cu, Zn and Mg, Ca Zn Fe Cu Yb with DOTA and DTPA, respectively. Consequently, the elimination of Mg and Ca from the Lu final solution produced was not found to be necessary, while the elimination of Cu, Fe, Zn and Yb from the Lu final solution was found to be necessary. On the basis of the knowledge obtained, the method of elimination of the competing metals will be developed.
Lu for radioimmunotherapy渡辺 智; 橋本 和幸; 渡辺 茂樹; 飯田 靖彦*; 花岡 宏史*; 遠藤 啓吾*; 石岡 典子
Journal of Radioanalytical and Nuclear Chemistry, 303(1), p.935 - 940, 2015/01
被引用回数：11 パーセンタイル：67.09(Chemistry, Analytical)No-carrier-added Lu produced via the 
Yb(n, 
) Yb 
Lu process was separated from the macroscopic amounts of the Yb target using reversed-phase ion-pair liquid chromatography. To produce a highly purified Lu solution capable of labeling antibodies, the metallic impurities were removed using cation, chelating ion, and anion exchange columns. After the elimination of metallic impurities, the concentrations of Ca, Fe, and Zn were reduced from 87, 340, and 77 ppb to 13, 18, and 9 ppb, respectively. Consequently, the labeling yield of the Lu -labeled antibody increased from less than 5% to 88%.
Luと二官能性キレート剤との錯形成渡辺 智; 橋本 和幸; 石岡 典子
no journal, ,
Lu-1,4,7,10-tetraazacyclododecan-N,N',N'',N'''-tetraacetic acid(DOTA)-抗体の標識が可能なLuの製造研究の一環として、Ca, Fe, Znに加えてMg, Cu, Yb存在下でのLuとDOTA及びdiethylenetriamine- N,N,N',N'',N''-pentaacetic acid (DTPA)との錯形成時の阻害について検討した。競合金属によるLuの錯形成阻害の強さは、DOTA及びDTPAにおいて、それぞれMg, Ca Fe Yb Cu, Zn及びMg, Ca Zn Fe Cu Ybの順序であった。以上の結果から、製造したLu最終溶液中のMg及びCaは除去する必要はないが、Cu, Fe, Zn及びYbは除去する必要があることが判明し、競合金属の除去方法の開発のための有用な知見を得ることができた。
